A Rare Bond: Exploring the Heart-Hand Connection in Holt-Oram Syndrome
Anil Kumar Gupta *
Department of Cardiology, GGMC & JJ Hospital, Mumbai, India.
Kalyan Munde
Department of Cardiology, GGMC & JJ Hospital, Mumbai, India.
Anant Munde
Department of Cardiology, GGMC & JJ Hospital, Mumbai, India.
Hariom Kolapkar
Department of Cardiology, GGMC & JJ Hospital, Mumbai, India.
Khalel Ahmed
Department of Cardiology, GGMC & JJ Hospital, Mumbai, India.
Salman Shaikh
Department of Cardiology, GGMC & JJ Hospital, Mumbai, India.
Prasad Jain
Department of Cardiology, GGMC & JJ Hospital, Mumbai, India.
Vighnesh Rane
Department of Cardiology, GGMC & JJ Hospital, Mumbai, India.
*Author to whom correspondence should be addressed.
Abstract
Holt-Oram syndrome is an autosomal dominant disorder characterized by upper limb abnormalities in association with congenital heart lesions. We present you a 42 years old female having ostium secundum atrial septal defect (OS-ASD) and congenital upper limb deformity. Her X-ray of hands showed bilateral abnormal carpal bones with underdeveloped thumb. This study highlights the importance of recognizing the heart-hand connection in Holt-Oram syndrome and presents the need for multidisciplinary care and early intervention.
Keywords: Holt-Oram syndrome, ASD, hand deformity